The substantial changes in this book reflect the many significant advances that have been made since publication of the second edition only three years ago. It therefore provides a greater understanding of the specific biological factors affecting pharmacokinetic processes of drug toxicity, and the practical uses of pharmacokinetic knowledge. The book remains a highly readable and informative account of the subject which greatly help students and postgraduates of pharmacy and pharmacology to develop a rational approach to the investigation and application of drugs. Salient Features · Emphasis is given to recent studies on age, genetics and disease. · Rearranged the book with new material and the size has grown accordingly. Review‘...It is a pleasure, therefore, to welcome the second edition of this book that has tablished itself as a standard reference on the subject...this is an important book for students of clinical pharmacology and pharmacokinetics, and also good value for money.’ The Pharmaceutical Journal (on the Second Edition)